PTD-DBM

PTD-DBM is a synthetic fusion peptide combining two functional domains: a Protein Transduction Domain (PTD) and a Dishevelled Binding Motif (DBM). The PTD component enables the peptide to cross cell membranes, a capability that would otherwise require specialized delivery systems for intracellular targets. The DBM component is derived from a region of the CXXC5 protein that normally interacts with Dishevelled (Dvl), an upstream scaffolding protein in the Wnt signaling pathway. By combining these two functional units, PTD-DBM was designed to penetrate cells and interfere with a specific intracellular protein-protein interaction relevant to hair follicle biology.